Standup comedian Max Brandel (Bobby Cannavale) leans on his life experiences for his comedy sets, and his son, Ezra, certainly provides plenty of inspiration. At 11 years old, brilliant and on the autism spectrum, Ezra is funny, spirited and, yes, sometimes a little chaotic. When Max and his ex-wife, Jenna (Rose Byrne), are advised to enroll Ezra in a specialized school and to start him on medication, the parents disagree about the proper course of action. Without Jenna’s permission, Max takes Ezra on a cross-country trip that the father and son won’t soon forget.